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Circulation 139, 20222031

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The Figure below diagrams a simplified view of the MHC cluster which spans 3.5 megabases of chromosome 6 and encompasses over 200 genes divided into three subregions termed class I, class II and class III

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However, their use is associated with increased risks of specific AEs, and some outcomes do not reach statistical significance across all populations, although the direction of effects remains largely consistent