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Nave T cells rely primarily on oxidative phosphorylation to generate ATP, whereas activated T cells shift their metabolism toward aerobic glycolysis (Warburg effect) to meet the demands of growth, proliferation, and effector functions, such as IFN- production (136)

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Best Pract Res Clin Endocrinol Metab 33(6):101367 Raza S, Rajak S, Upadhyay A, Tewari A, Sinha RA (2021) Current treatment paradigms and emerging therapies for NAFLD/NASH

both increase ROS accumulation in key regions like the gut and brain, contributing to cellular senescence, neuroinflammation, and cognitive dysfunction (Wang et al., 2010