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This process drives dysregulation of macrophage polarization and excessive production of pro-inflammatory cytokines and induces synovial fibroblast proliferation and activation

Although GIP does not interact with pancreatic -cells, it has myriad physiological functions, including enhancing glucose-dependent insulin secretion during the postprandial phase, increasing -cell proliferation, and antiapoptotic and neogenetic effect on the -cells

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doi: 10.1038/s41598-022-05078-1 84 SavaskanN

And if I dont, youre more likely to be oxidatively challenged and then most folks are not walking around with antioxidants that are sufficient to handle their oxidative load