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As another example, consider a new ACO inexperienced with performance-based risk Medicare ACO initiatives that enters the BASIC track's glide path at Level A for an agreement period beginning on January 1, 2026, based on the criteria used to determine ACO participation options specified at 425.600(g)

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The PIONEER clinical trial program showed participants taking oral semaglutide lost between 7% and 13% of their baseline body weight over 68 weeks, depending on dose level and study cohort