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Leflunomide has been investigated in several clinical trials as an anti-cancer therapy, including metastatic triple negative cancers (NCT03709446), add-on therapy to mitoxantrone in stage IV prostate cancer (NCT00004071), add on to vemurafenib in metastatic melanoma (NCT01611675), as treatment for multiple melanoma (NCT02509052), anaplastic astrocytoma (NCT00003775), and glioblastoma multiforme (NCT00003293)