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Followed by the speed-expansion phase in which pharmacological ascorbic acid was administered at the MTD, but the MTD was not reached and the RP2D was established to be 1.5 g/kg/day, days 13, with mFOLFOX6 or FOLFIRI

cGAS in action: expanding roles in immunity and inflammation

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PQQ is remarkably stable and can undergo up to 20,000 redox cycles before it is finally used up

In a study performed on 75 subjects (3 neonates, 25 infants, 25 children, and 22 adolescents), a PK model was developed from data following intravenous APAP administration (Zuppa et al., 2011)