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Depigmentation and/or subcutaneous atrophy can occur in thin patients, especially those with dark skins, and they should be informed of this before giving consent

Some diseases that make you at higher risk of having a deficiency include gastritis, digestive diseases such as celiac disease or Crohns disease, HIV, or an alcohol abuse disorder

Patients who skip the break period and run continuous cycles do not get proportionally better outcomes and risk diminishing returns on the therapeutic response

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A common approach is to add a volume of water that makes the math simple for future measurements