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Reproductive toxicity, teratogenicity, and long-term endocrine effects have not been robustly studied

ASSOCIATE PROFESSOR DANIEL BELSKY, EPIDEMIOLOGIST, COLUMBIA UNIVERSITY: We need measurements that we can take at the beginning of a trial and again after three, six, twelve months of intervention to tell us whether whatever we're doing is moving our biology in the direction that would be consistent with slowing aging and extending healthy lifespan

Jan 2019;80(1):120-127 e2

ER formulations close the gap considerably Shortest IR window Legal Status Adderall Schedule II controlled substance Requires prescription and routine prescriber monitoring Schedule II Vyvanse Schedule II controlled substance Same federal classification as Adderall despite lower misuse profile Schedule II Ritalin Schedule II controlled substance Prescription required

They are different mechanisms and may be useful for different concerns