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MSC-Exos have demonstrated their therapeutic ability to improve OA by reducing inflammation, preventing ferroptosis, and promoting bone cell growth through the GOT1/CCR2/Nrf2/HO-1 signaling pathway [174]

As feedback mechanisms maintain the hormonal levels, the increased serum concentration of growth hormone (GH) stimulates another endogenous hormone called somatostatin, also known as growth hormone inhibiting hormone (GHIH)