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Alkaloids such as isoliensinine can inhibit the TGF-1/Smad2/3 signaling pathway in hypertensive-associated renal fibrosis, while the berberine alkaloid has shown suppression of the NFB signaling pathway in renovascular complications [241, 242]

Approximately 85% of patients with diabetes mellitus have Type 2 diabetes mellitus (T2DM), which can be a result of genetic predisposition, environmental factors, or a combination of these two [4]

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