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Compounded therapy, by contrast, is not FDA-approved

However, causality is complex and not fully established in all cases

A better understanding of these adaptive mechanisms of gastric mucosa after RYGB and VSG and their exploitation will help in the development of new approaches to bariatric surgeries and possibly allow to replace them with less invasive and gastric-targeted endocrine therapies for the treatment of obesity-related diabetes

And patients who could benefit - the normal-weight person with insulin resistance, fatty liver, and creeping inflammatory markers - never get offered them

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