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Hyperpigmentation While melanotic macules are one result of hyperpigmentation, there are a few other avenues through which this excess melanin can cause dark spots on the lips

Additional mechanistic references explore molecular frameworks related to lipid metabolismassociated signaling pathways and peptide-mediated molecular interactions evaluated through analytical and observational research approaches

Arbutin: Reduces melanin production, helping to fade dark spots and pigmentation

They regulate appetite signals, reduce cravings, and help normalize blood sugar

5.6 Asbestos Asbestos, a group of naturally occurring fibrous minerals, has long been recognized as a potent environmental carcinogen, particularly associated with lung cancer, mesothelioma, and asbestosis