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(28152637) IV L-arginine might be a reasonable consideration in the following situations: i) Moderate to severe hyperammonemia, without immediate access to hemodialysis ii) Persistent hyperammonemia, despite hemodialysis iii) Hyperammonemia which poses an immediate threat to life (e.g., moderate to severe hyperammonemia with evidence of cerebral edema) A reasonable dose may be: (22642880) Loading bolus of 250 mg/kg (1.2 mM/kg) over 2 hours

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This means that to deliver equivalent therapeutic effects, oral versions require much higher doses, increasing costs and side effects while producing variable results depending on food intake, gastric pH, and individual metabolism

Thus, DPP-4 inhibitors could easily act on pancreatic islets to specifically protect the local pool of GLP-1 produced by alpha cells

Hindering Glucagon production