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Hu S, Dan W, Liu J, Ha P, Zhou T, Guo X, et al

Dissecting the heterogeneity in T-cell mediated inflammation in IBD

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The progression from single-agonist (semaglutide) to dual-agonist (tirzepatide) to triple-agonist (retatrutide) tells a clear story about where obesity treatment is heading

Changes are quite likely more related to increased systemic inflammation, BBB disruption, and cognitive outcome deterioration (Silva et al., 2020)