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2005 Oct;112(10):1784-9 7.0 7.1 Decatur CL, Ong E, Garg N, Anbunathan H, Bowcock AM, Field MG, Harbour JW
28-30 However, an unblinded randomized controlled trial (RCT) comparing the efficacy of metformin (500 mg 3 times daily) with rosiglitazone (4 mg/d), another T2DM medication, on AN neck lesions in patients who were overweight and obese found no significant effects in lesion severity and only modest improvements in skin texture in both groups at 12 weeks following treatment initiation
Compounded medications are not FDA-approved and may be prescribed only when a licensed prescriber determines a clinically significant difference for an identified patient