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all P -values are reported in Supplementary Table 1 and source data are available in the Dryad repository doi:10.5061/dryad.905qfttvz)

TRT is contraindicated or needs specialist clearance for men with prostate or breast cancer, an abnormal prostate exam or high PSA, high hematocrit (thick blood), untreated severe sleep apnea, uncontrolled heart failure, a recent heart attack or stroke, a clotting disorder, or those trying to conceive soon

The authors would like to note that the actual size of glutathione in a non-aggregated state is outside of 0.87 nm detection limit for what can be measured accurately by the dynamic light scattering technique

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The commenter was concerned this could suppress patient volume, exacerbate disparities, and create challenges in recruiting clinical talent, ultimately undermining patient safety outcomes