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[21] Within cells, cyanocobalamin is converted to methylcobalamin and 5- deoxyadenosylcobalamin, coenzymes that participate respectively in homocysteine remethylation to methionine and in the isomerization of methylmalonyl-CoA to succinyl CoA, reactions essential for DNA synthesis, erythropoiesis, and myelin maintenance
Although distinct differences exist between methylcobalamin and cyanocobalamin, both have beneficial effects on health and can prevent B12 deficiencies ( In fact, one study found that treating seven B12-deficient people with oral methylcobalamin normalized vitamin B12 levels in their blood within just 2 months ( Similarly, another study showed that taking cyanocobalamin capsules for 3 months also increased vitamin B12 levels in 10 people with pernicious anemia, a condition caused by impaired B12 absorption ( Both types of the vitamin may also provide other health benefits
Pernicious anaemia (PA) is an autoimmune condition which prevents the absorption of B12 in the gut due to a depletion in the main protein involved in B12 absorption
Pharmacological Reviews, 1998
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