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2015;10:e0117745

Effects of yRNA Modification on Translational Accuracy Depend on Intrinsic Codon-Anticodon Strength

Duarte, University of Coimbra, Portugal

Studies in rats exposed to circadian-disrupting xenobiotics showed Epithalon prevented disturbances in diurnal dopamine rhythms in the median eminence and normalized norepinephrine dynamics in the medial preoptic area

Treated mice showed decreased susceptibility to muscle damage, improved muscle strength, reduced PARP activity, increased NAD + levels, and elevated mitochondrial function 254 , thus suggesting a potential therapeutic benefit of NR supplementation in DMD