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Pigmentation effects accumulate over days to weeks of repeated administration, because melanogenesis is a slow process dependent on melanocyte turnover (4-6 weeks for a complete epidermal cycle)

Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction

Adults following a calorie-restricted eating pattern or experiencing reduced appetite

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These substrates include aconitase (Aco) [40], uracil-DNA glycosylase isoform 1 [41], frataxin [42], cystathionine -synthase [43], DAP3-binding cell death enhancer 1 [44], mitochondrial calpain 10 [45], 5-aminolevulinic acid synthase [46], and more