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doi: 10.1186/s41983-018-0033-z 24
Neurology 67(2):315318
Chronic stress suppresses your own endogenous GLP-1 system within 30 minutes (Zhang et al
The latter hypothesis derives from observations that GIP modulates vascular tone across peripheral vascular beds by enhancing endothelial nitric-oxide synthesis through eNOS activationan effect abolished by CaMKK, PLC, or AMPK inhibitionand demonstrates anti-inflammatory actions in adipose tissue and endothelium that correlate with increased cAMP signaling in select vascular beds, though a direct cAMP-dependent mechanism underlying its anti-inflammatory effect has yet to be conclusively established 49
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