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A systematic literature search was performed, and network meta-analysis using random-effects model that generated mixed treatment comparison estimates was employed to assess the comparative efficacy of these drug classes on clinical (menstrual frequency, pregnancy rate and proportion of patients with regular menstrual cycles), anthropometric, hormonal, and metabolic parameters

GCH1 is a rate-limit enzyme of BH4 synthesis, which functions as an antioxidant in parallel with CoQ10 to block lipid peroxidation and ferroptosis

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Providers may prescribe compounded medications based on patient needs or due to medication shortages