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Broader use also increased the number of people potentially exposed to delayed gastric emptying, severe gastrointestinal symptoms, and other reported complications

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According to these data, only 8.5% of HSA is renewed daily, thus allowing a long exposure time to drugs, which can favor the formation of drug-HSA adducts, as those detected in vitro and in the serum of patients (Jenkins et al., 2009

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in Mouse Genetics: Methods and Protocols (eds