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In terms of the specific mechanism, a recent study suggested that the increased FAO and CPT expression by CS challenge in airway EpiC might exploit fat storage in adipose tissues to meet elevated FA demands within the lungs under stress conditions

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Preclinical and observational data available for the individual components

Intraperitoneal administration in animal models shows a shorter half life (one to two hours) because the peritoneal membrane allows faster systemic absorption and subsequent liver exposure

Moreover, presence of sequences with different subcellular localizations in the same phylogenetic group inferred the possibility of gene duplication events in formation of some APX/GPX sequences