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doi: 10.1002/alz.12008 225 LittleC

This diversion leads to the accumulation of sorbitol and fructose within cells, increasing intracellular osmolarity and causing osmotic stress

Nazwa BPC pochodzi od okrelenia Body Protection Compound , czyli "zwizek ochronny organizmu"

Disrupted iron homeostasis constitutes a primary trigger for ferroptosis initiation

However, in tauopathies such as AD, as well as in hibernation, tau undergoes hyperphosphorylation catalyzed by various protein kinases, including but not limited to glycogen GSK3, cyclin-dependent kinase 5 (CDK5), and protein kinase A (PKA) [103,104,105], accumulating an excess of 7-10 phosphate groups [106]