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Pycnogenol supplementation improves health risk factors in subjects with metabolic syndrome

Studies have shown that inhibition of p53 in tumor cell growth is related to increased ferroptosis sensitivity ( via system Xc(-) or by upregulating recombinant spermidine/spermine N1-acetyltransferase 1 (SAT1) downstream of p53, which is involved in polyamine metabolism ( Transcription Factor Pathways A major transcription factors, such as nuclear factor-erythroid 2-related factor 2 (NFE2L2, also known as NRF2) ( in vitro and in vivo (Figure 2)

doi: 10.1016/j.cbi.2023.110684

selectively overexpressed SLC7A11 in the myocardium and found that it can increase cellular GSH levels and prevent FTH deficiency-mediated iron death [76]

Biological sex and DNA repair deficiency drive Alzheimer's disease via systemic metabolic remodeling and brain mitochondrial dysfunction