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Overexpression of Drp1 and Atg5 in cardiomyocytes or inhibition of p53 to increase autophagic flux can prevent symptoms such as myocardial hypertrophy and aging [230, 231]
Even the single study that did suggest a possible link found only a handful of cases in people with diabetes, a group already at increased risk for eye disease and nerve disorders
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The timing should be individualised based on the patient's recovery rather than following a fixed timeline
Some show improved markers of mitochondrial efficiency, especially in populations with higher metabolic stresspeople in large deficits, individuals on GLP-1 medications, high-volume endurance athletes, and adults with insulin resistance
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