Nature 414, 514521
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In order to overcome the short half-life of GLP-1 and improve stability, researchers at Novo Nordisk used genetic engineering techniques to modify the amino acid sequence of GLP-1 to produce a more stable and long-lasting analogue, insulin-like Peptide-1 receptor agonist (GLP-1 RA)
PlexusDx providers review your complete medication list, current blood glucose patterns, and steroid indication during the intake process to create a treatment plan that accounts for metabolic interference
The primary endpoints were clinical remission for UC patients (mMS 2) and endoscopic response for CD patients (50% SES-CD reduction), with inclusion criteria requiring IBD diagnosis for 3 months, moderate to severe disease activity, and inadequate response to prior therapies, while excluding patients with active infections, malignancy, immunocompromised states, or pregnancy