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In IBDs, the gastrointestinal mucosa becomes damaged

Proc Natl Acad Sci USA 103(33):1249312498 Shaul ME, Fridlender ZG (2017) Neutrophils as active regulators of the immune system in the tumor microenvironment

The idea that there is a built-in preference for finishing all steps on one strand before starting the other suggests that all end structures requiring a processing step before ligation may favor a model 2 path

Kobayashi H, Yamada Y, Morioka S, Niiro E, Shigemitsu A, Ito F

CaMKK2 dysfunction may play an underlying role in this phenomenon as genetic deletion of Camkk2 in hippocampal neurons, myeloid cells and immortalized cell lines (HEK293 and HepG2) results in mitochondrial dysfunction that causes a similar switch in cellular energy generation from oxidative phosphorylation to glycolysis [43, 201, 202]