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However, findings in humans have been variable

The central case after price cuts and a modest volume response translates to about $36.5 billion

Efficacy and Safety of Once-Weekly Semaglutide Versus Once-Daily Insulin Glargine as Add-on to Metformin (With or Without Sulfonylureas) in Insulin-Naive Patients With Type 2 Diabetes (SUSTAIN 4): A Randomised, Open-Label, Parallel-Group, Multicentre, Multinational, Phase 3a Trial

Goldstone AP, Holland AJ, Hauffa BP, Hokken-Koelega AC, Tauber M

The FDA-approved criteria require a BMI of 30 or greater (obesity), or a BMI of 27 or greater with at least one weight-related comorbidity such as type 2 diabetes, high blood pressure, high cholesterol, obstructive sleep apnea, or cardiovascular disease