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Introduction Acute coronary syndromes (ACS), such as unstable angina pectoris (uAP), non-ST-elevated myocardial infarction (NSTEMI), and ST-elevated myocardial infarction (STEMI), and chronic coronary syndromes (CCS) replacing the term stable angina in 2019 ESC guidelines, are prevalent conditions with major contributions to morbidity and mortality ( Although recent reviews have described the role of GLP-1 RAs on cardiovascular risk in general, there is a lack of evidence synthesis on local actions of GLP-1 RAs in coronary arteries and the link of these mechanisms to coronary events ((Figure 1)

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