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And in another clinical trial, injections of 15-mg doses of tirzepatide (the active ingredient in Eli Lilly's weight-loss injectable Zepbound) resulted in an average of about 21 percent body-weight reductions after 72 weeks

Currently, research is ongoing into GA and its derivatives, yet a deeper understanding of their clinical application and disease-specific mechanisms is still needed

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These medications are contraindicated in patients with: Personal history of medullary thyroid carcinoma Family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) For patients with standard hypothyroidism (typically autoimmune thyroiditis or post-ablation), these contraindications do not apply