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Despite this initial disappointment, Soleno Therapeutics initiated an open-label follow-up trial, C602, to see how the drug performed over a longer period

Meng, Y., et al

Moreover, liraglutide 3.0 mg (i.e., the dose level approved for weight management for this GLP-1 RA) in combination with lifestyle intervention markedly reduced the presence of visceral fat over a period of 40 weeks ( The reductions in ROS and systemic inflammation, in combination with improvements in the other cardiometabolic parameters, are also thought to mediate the substantiated but so far formally unconfirmed kidney-protective effects of GLP-1 RAs, which may also directly or indirectly carry a HF-related benefit, considering that CKD is a prominent risk factor for HF (von Scholten et al., 2022)

Detailed statistics are in Supplementary Table 1

Combination therapies that unify the benefits of SGLT2 inhibition with other glucose-lowering mechanisms (like GLP-1 agonism) are also in development to provide multifaceted treatment approaches