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On the one hand, microbial metabolites such as short-chain fatty acids and secondary bile acids stimulate GLP-1 secretion from intestinal L-cells and modulate its circadian rhythm, linking microbial activity to satiety regulation, glucose control, and fat metabolism (Figure 2, left)

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When injections are the right choice When blood tests or clinical context indicate deficiency or malabsorption, intramuscular B12 is an appropriate and often necessary treatment

82 While the Warburg effectcharacterized by increased aerobic glycolysisis a metabolic hallmark observed across many tumor types, CSCs exploit this and other metabolic programs in a highly plastic manner to support their survival and proliferative advantage under stress

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