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Preconditioning-Induced facilitation of lactate release from astrocytes is essential for brain ischemic tolerance

Moreover, NO seems to be the only mediator of cell proliferation arrest through the ERK1/2-p53 signaling pathway ( FIGURE 1 Next to this evidence, in our laboratory it has been demonstrated that GSH depletion modulates the peroxisome proliferator-activated receptor gamma, co-activator 1 alpha (PGC-1) expression and its downstream metabolic pathway in neuronal and skeletal muscle cells ( Figure 1 )

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Seizure and Stroke Experiments DSIP and analogues have been examined in induced seizure and experimental stroke models

All TMT labeled samples were combined in equal amounts in a new tube (200 g) and were run on Mass spec after fractionation