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1,2 Although the clinical trials of amitriptyline are old and involved small numbers of patients, a systematic review revealed that amitriptyline tended to show superiority over duloxetine, pregabalin, and milnacipran

188 Dietary composition can affect a number of factors that influence brain function, including neurotransmitter synthesis and signaling, release of hormones by the gut, the composition of the gut microbiota, and gene expression patterns