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Alpha lipoic acid boosts glutathione production and adds an additional layer of antioxidant protection

The chemical mechanism by which glutathione -S- transferase is inactivated by the glutathione acrylate analog is likely based on the presence in the tertiary structure of the enzyme of a docking site where glutathione is bound and its free thiol group is deprotonated by a facing amino acid which acts as a strong proton acceptor [129]

the lesions may be seen in the oral mucosa and tongue too They form discolored flat and asymmetric patches less than 1 cm in size The color of the macules may be uniform or non-uniform

Molderings GJ, et al

Interferon regulatory factor 9 protects against cardiac hypertrophy by targeting myocardin