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The researchers wrote that their findings add to growing evidence that GLP-1s may reduce brain inflammation, preserve the protective barrier around the brain, and reduce cell and tissue damage

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However, depletion of another -KG-producing enzyme, PSAT1, but not GDH1 greatly reduced AMPK expression in IMR90 cells (Supplementary Fig

In one clinical trial, PNS shows renoprotective effects on reducing albuminuria, proteinuria and Scr in patients with DKD (Tang et al., 2020)