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Throughout infancy, the microbiota composition is dynamically shaped by dietary factors, antibiotic exposure, infections, and environmental stimuli [28]

ZengQShenJChenKZhouJLiaoQLuKet alThe alteration of gut microbiome and metabolism in amyotrophic lateral sclerosis patients

Available from: Gupta R, Srivastava D, Sahu M, Tiwari S, Ambasta RK, Kumar P

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These include increased expression of glutamate cysteine ligase (also referred to as -glutamylcysteine synthetase) to promote GSH synthesis (272), upregulation of glutaredoxins that catalyze the reduction of S-glutathionylated proteins in the mitochondrial membrane (22), and increased expression and activation of the transcription factor, nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which regulates the expression of several genes essential for GSH synthesis and homeostasis (188)