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Clinical trials reveal that 10-15% of participants taking GLP-1 medications like Wegovy or Mounjaro qualify as non-responders, losing less than 5% of their body weight

Jiang, Y.-H

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For example, in a phosphoethanolamine-enriched TME, its enhanced conversion into phosphatidylethanolamine within CD8 + T cells depletes the second messenger diacylglycerol, thereby impeding immune activation [71]