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Importantly, supplementation can **increase** measurable NAD+ metabolism: in a 2018 randomized, placebo-controlled crossover trial published in Nature Communications by Martens and colleagues at the University of Colorado Boulder (24 healthy middle-aged and older adults), 1,000 mg/day of the NAD+ precursor nicotinamide riboside (500 mg, twice daily) elevated NAD+ in blood cells by roughly 60% versus placebo over 6 weeks, with no serious adverse events reported

Studies have indicated that when nonsurgical and surgical treatment options are examined, the outcomes are not significantly different

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doi: 10.1016/j.freeradbiomed.2009.07.023 34 SainiRSinghS

Because of the extra high levels of melanin production, skin of color is especially prone to hyperpigmentation