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The nature of the stepwise escalation required to attain higher dose levels of 10 and 15 mg does not permit us to evaluate these doses in a single-dose hepatic impairment study

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The trial lasted 80 weeks , while a smaller group of severely obese participants continued taking the medication for 104 weeks

Trial STEP TEENS (Weghuber et al., NEJM 2022) Design Phase 3 / 68 weeks Population 201 adolescents (12-17) with obesity Key result -16.1% BMI reduction vs +0.6% placebo