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Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications

For students, researchers, and curious readers approaching GHK-Cu for the first time, the most accurate framing is that of a naturally occurring copper-binding tripeptide with substantial research literature across five decades, with well-established coordination chemistry and well-grounded connections to copper-dependent extracellular matrix biology, with substantial cosmetic-ingredient regulated use, and with ongoing research conversations about the breadth and specificity of the broader transcriptomic effects

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