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After two successful decades at the company, DiMarchi left that role for IUs Department of Chemistry in the College of Arts and Sciences, in large part to pursue the increased independence of an academic research position

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Monitoring results, tweaking doses, and troubleshooting issues requires consistent attention over protocol duration

AE leading to drug discontinuation were observed in 16% of participants with the 12 mg dose, but the overall incidence of SAE was low (up to 6-8%)

This proposes challenges in depth and quality of evidence as the literature still provides little to no true evidence-based guidance regarding the pre-operative duration of fasting time or medication, withholding time for this patient population