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Many studies have compared berberine to the popular oral diabetic medications known as metformin 13

l-dopa) can cross the BBB and reach brain tissue via l-type amino acid transporter-1 (LAT-1), the member of solute carrier (SLC) family present at the brain endothelium and diverse brain cells [6]

Although the protective role of glycocalyx in SAP-associated MODS has been explored, current studies mainly focus on the acute phase, with limited understanding of the glycocalyx repair mechanisms and long-term organ recovery [4, 133]

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However, the cost implications cannot be ignored