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NICE guidelines recommend evidence-based weight management through dietary modification (600 kcal/day deficit), 150300 minutes weekly moderate-intensity physical activity, and behavioural change strategies

Serious adverse events have not been widely reported, but this may reflect the relatively small number of people who have used the compound and the limited reporting mechanisms available

A deficiency in vitamin B12 can show up in ways that are easy to dismiss as just stress or a busy schedule

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