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The findings of a study suggest that exploring the potential of Chk1 inhibitors as a targeted therapy may be a promising treatment approach for patients with clear-cell ovarian cancer, presenting a new opportunity for combination therapy (150)

Inhibitors do not convert TGR into an NADPH oxidase Several covalent inhibitors of TGR are electrophilic compounds reacting with the Sec residue at the C-terminus, which induce a transition in the enzyme from an antioxidant to a pro-oxidant with increased NADPH consumption 20,45