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In turn, adiponectin can ameliorate NAFLD-associated liver abnormalities by regulating the oxidation of hepatic fatty acid and the activity of acetyl-CoA carboxylase and fatty acid synthase, two key enzymes involved in fatty acid synthesis (51)

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These individuals often show blunted GLP-1 responses after meals, suggesting that improving baseline metabolic health can restore more robust GLP-1 signaling over time (Huber et al., 2024)

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