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Van Bodegraven B, Vernon S, Eversfield C et al

Still, these findings are largely based on case series rather than randomized trials

Recent imaging studies reveal that BBB breakdown and glymphatic system impairment associated with gliosis occur early in aging, particularly in the hippocampus, and are exacerbated in mild cognitive impairment, correlating with pericyte injury (Montagne et al., 2015)