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Notwithstanding the fact that the aforestated investigations have uniformly demonstrated that GLP-1 RAs are endowed with a multiplicity of cardioprotective efficacies, the consistency of such findings has not been ubiquitously maintained throughout all the research undertakings [101]

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NICE guidance on GLP-1 receptor agonists (NG28 for diabetes, TA875 for weight management) acknowledges these gastrointestinal effects and recommends that healthcare professionals counsel patients about expected side effects and management strategies before initiating treatment