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During the initial treatment period with methylcobalamin, pulmonary edema and congestive heart failure have reportedly occurred early in treatment with parenteral methylcobalamin

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The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007

In rodent knockout models where beta-3 adrenergic receptors were removed, the lipolytic response to AOD 9604 was eliminated, confirming the receptor-specific mechanism